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BAXTER
LAUNCHES MESNEX (mesna) TABLETS
Oral Form of Uroprotectant
Offers a Convenient Dosage Alternative for Patients Receiving Chemotherapy
Treatment
Deerfield, Ill., July
16, 2002 -- Baxter Healthcare Corporation announced today that it is launching
an oral formulation of Mesnex (mesna) Tablets as a prophylactic agent
to reduce the incidence of ifosfamide-induced hemorrhagic cystitis.
Bristol-Myers Squibb Oncology will be co-promoting Mesnex (mesna) Tablets
during the initial launch period, including support from the company's
leading oncology sales force. Bristol-Myers Squibb Oncology currently
markets and distributes intravenous Mesnex (mesna) Injection and Ifex
(ifosfamide for injection) for Baxter.
Currently, cancer patients undergoing treatment with the chemotherapy
agent ifosfamide also receive Mesnex (mesna) Injection to help protect
their urinary system from hemorrhagic cystitis as the ifosfamide is eliminated
from their body. Adequate levels of Mesnex must be maintained in the urinary
system during the entire course of elimination of the ifosfamide. Since
mesna has a shorter therapeutic half-life when compared to ifosfamide,
successful treatment requires repeated dosings of Mesnex. Currently, intravenous
Mesnex administration involves a 15-minute intravenous infusion at zero,
four, and eight hours after starting ifosfamide.
With the availability of Baxter's new Mesnex (mesna) Tablets, recently
approved by the U.S. Food and Drug Administration (FDA), patients receiving
ifosfamide will receive their initial dose of Mesnex intravenously at
the time of ifosfamide administration, and then follow up with Mesnex
(mesna) Tablets two and six hours following the ifosfamide treatment.
Previously, patients were required to remain at the site of care for several
hours to receive the follow up doses of Mesnex intravenously.
"Mesnex Tablets offer the potential to significantly shorten the
amount of time that patients have to spend in the infusion room,"
explained Laurence H. Baker, Professor of Internal Medicine, Division
of Hematology and Oncology, and Director for Clinical Research at the
University of Michigan's Comprehensive Cancer Center, who served as lead
investigator in clinical trials for Mesnex (mesna) Tablets. "This
is significant because it allows doctors to treat patients in a clinic
or outpatient setting, rather than hospitalizing patients."
"Our objective is to help improve the treatment of cancer patients
worldwide through the development, production, marketing and sale of new
and improved products," said Cynthia Collins, president of Baxter's
Oncology business. "Mesnex Tablets is a great example of how we can
leverage our core technical competencies to help simplify patient care.
Our relationship with Bristol-Myers Squibb Oncology enhances our ability
to broadly communicate the availability of this product."
Baxter's global oncology portfolio includes several leading chemotherapeutics
(including cyclophosphamide, ifosfamide and mesna), cell processing products,
and a variety of pain management and nutritional products and systems
used in the administration and support of those therapies.
Baxter Healthcare Corporation is the principal domestic operating subsidiary
of Baxter International Inc. (NYSE: BAX), a global health care company
that, through its subsidiaries, provides critical therapies for people
with life-threatening conditions. Baxter's bioscience, medication delivery
and renal products and services are used to treat patients with some of
the most challenging medical conditions, including cancer, hemophilia,
immune deficiencies, infectious diseases, kidney disease and trauma.
About Mesnex (mesna)
Tablets
Mild hypersensitivity to systemic anaphylactic reactions to mesna have
been reported, especially in patients with autoimmune disorders who were
treated with cyclophosphamide and mesna. Mesna did not prevent hemhorragic
cystitis in up to 6% of patients treated. The most frequent side effects
reported with oral mesna are nausea (54%), vomiting (38%), fatigue (20%),
anemia (18%), leukopenia (18%), asthenia (18%), and constipation (18%).
For complete Mesnex
(mesna) Tablets prescribing information, please see Baxter's web site
at www.baxter.com/mesnex/.
About Ifex (ifosfamide
for injection)
Ifex (ifosfamide for injection), used in combination with certain other
approved antineoplastic agents, is indicated for third line chemotherapy
of germ cell testicular cancer. It should ordinarily be used in combination
with a prophylactic agent for hemorrhagic cystitis, such as Mesnex (mesna)
Injection.
In patients receiving
Ifex (ifosfamide for injection), as a single agent, the dose-limiting
toxicities are myelosuppression and urotoxicity. CNS toxicities such as
confusion and coma, which may require cessation of therapy, have been
associated with Ifex administration.
For complete Ifex
prescribing information, please visit www.ifex.com
or the Bristol-Myers Squibb Company website at
www.bms.com.
Baxter and Mesnex
are trademarks of Baxter International Inc. and its affiliates. Ifex is
a trademark of Bristol-Myers Squibb Company.
FOR ADDITIONAL
INFORMATION:
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- Media Contact:
- Deborah Spak, 847-948-2349
- Investor Contacts:
- Neville Jeharajah,
847-948-2875
Mary Kay Ladone, 847-948-3371
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