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BAXTER HIGHLIGHTS
GROWTH INITIATIVES AT ANNUAL INVESTOR CONFERENCE
Baxter
Plans for Further Expansion of BioScience Business
with Announcement of 5th Production Suite in Neuchâtel, Switzerland,
and Significant Increases in Recombinant Factor VIII Production Yields
Vaccines Growth
to be Fueled by Influenza Vaccine Approvals and Increased Manufacturing
Capacity
DEERFIELD, Ill., March
14, 2002 -- Baxter International Inc. (NYSE:BAX) today outlined plans
during its annual investor conference to further accelerate the company's
growth in the years ahead. The acquisitions, expanded manufacturing capacity
and licensing agreements the company has announced already this year,
together with Baxter's core strengths, create considerable new opportunities
for growth.
"We expect to accelerate our future sales and earnings growth not
only through continued emphasis on operational excellence and financial
discipline, but also by leveraging our proprietary technology platforms
and manufacturing capabilities, and by improving global access to health
care," said Harry M. Jansen Kraemer, Jr., chairman and chief executive
officer.
Baxter's chief financial officer, Brian Anderson, reiterated the company's
financial commitments for 2002 and outlined its goals for future sales
and earnings growth acceleration. The company's commitments for 2002 include
sales growth in the low-teens, earnings per share growth in the mid-teens
and operational cash flow of $500 million. Baxter's longer-term financial
goals include accelerating sales growth from the low-teens to mid-teens,
raising earnings per share growth from the mid-teens to high-teens, and
increasing the amount of operational cash flow generated after capital
expenditures from $500 million to over $700 million.
BioScience Continues Aggressive Growth Trends
At the conference, the company outlined plans for continued BioScience
growth, including ongoing expansion of manufacturing capacity for plasma-derived
and recombinant proteins and vaccines, as well as continued portfolio
enhancement through internal research and development efforts, collaborations
with partner companies and a broadened therapeutic focus.
Baxter announced its intention to further expand manufacturing capacity
for recombinant Factor VIII (rFVIII) for the treatment of hemophilia A
and other recombinant therapeutic proteins. In addition to three recombinant
manufacturing suites already in operation at its Thousand Oaks, California,
facility and a fourth on track for regulatory approval in late 2004, the
company announced today that it plans to invest in a fifth suite for the
processing of recombinant therapies at its multi-purpose manufacturing
facility in Neuchâtel, Switzerland. With this additional suite at
its Neuchâtel facility, Baxter will have a total of nine suites
for production of recombinant Factor VIII therapy and other recombinant
therapeutic proteins.
"With the investments we have made in expanding production capacity
through additional suites and significant yield improvements, by 2005
we expect to produce a total of two-and-one-half billion units of recombinant
Factor VIII therapy from just six out of our nine production suites,"
said Thomas Glanzmann, president of Baxter's BioScience business. This
will allow Baxter the flexibility to produce either recombinant Factor
VIII or other recombinant therapeutic proteins with the other three multipurpose
suites in Neuchâtel.
Another significant growth opportunity is in vaccines, an area in which
the company continues to invest in expanded manufacturing capacity, advance
its proprietary vero-cell platform and meet important clinical and regulatory
milestones. Earlier this week, Baxter announced the location of two state-of-the-art
manufacturing facilities for cell-culture derived and recombinant vaccines.
The two facilities, located in Krems, Austria, and Bohumile, Czech Republic,
will allow Baxter to produce approximately 42 million doses of InfluJect
annually by 2006. Baxter recently received regulatory approval in the
Netherlands for InfluJect, its novel influenza vaccine which is produced
using Baxter's proprietary vero-cell technology. InfluJect clinical trials
will be initiated this year in the United States, and a large-scale commercial
launch is planned for Europe in 2004.
In reviewing Baxter's core technical competencies, Chief Scientific Officer
Norbert Riedel highlighted the vero-cell technology and described how
it offers significant benefits over other vaccine platforms by excluding
any added proteins or raw materials derived from human or animal sources
in the manufacture, purification and formulation of its vaccines. This
technology has the potential to offer such advantages as a protein- and
serum-free production medium, shorter production cycle, significantly
higher yield and purity, and no antibiotics, egg proteins nor mercury-containing
preservatives.
Also highlighted as an area of innovation was Baxter's technology program
to enhance blood safety. Baxter, with its development partner Cerus Corporation,
anticipates European regulatory approval of the INTERCEPT Platelet System
in the first half of this year, with U.S. filing later in 2002. The companies
are conducting Phase IIIc and III clinical trials in the US for the INTERCEPT
Plasma System and Red Blood Cell System, respectively.
Medication Delivery's Technology Platforms Make it Partner of Choice
David Drohan, president of Baxter's Medication Delivery business, showcased
the company's proprietary drug formulation, manufacturing, and container
and delivery platforms that are used in partnership with clinicians and
pharmaceutical companies to improve patient care and reduce health-care
costs. Currently, the company has more than 40 agreements with pharmaceutical
companies to formulate medications in a variety of delivery platforms
that make injectable drugs easier, safer and more efficient to prepare,
and has at least two dozen additional collaborations under development.
During the conference, Baxter executives also highlighted new technologies
that will allow insoluble drugs to be formulated so that they can be administered
to patients in an easier, more effective manner. One of the most challenging
issues in the development of many pharmaceutical products is formulating
a drug molecule so that it can be administered to patients -- more than
one-third of drugs listed in the US Pharmacopoeia and about 50 percent
of new drug molecules are insoluble. As a result, many drugs have sub-optimal
formulations and many otherwise promising compounds never reach the market
due to problems with insolubility. To help Baxter's pharmaceutical company
partners solve problems with solubility, in 2001 Baxter expanded the company's
capability to formulate new and existing drug entities with the launch
of NanoEdge Technologies, a toolbox of manufacturing and formulation technologies
that have been either internally developed or acquired through exclusive
licensing agreements with other advanced drug delivery companies.
In addition, Baxter recently agreed to make an equity investment in Epic
Therapeutics, a privately held, advanced drug delivery company located
in Boston. Epic Therapeutics has developed a proprietary process for forming
drug molecule proteins into microspheres for sustained release through
various routes of administration, including inhalation and injection.
Epic Therapeutics and Baxter's BioScience business recently initiated
a research collaboration to explore the feasibility of applying Epic's
technology, called ProMaxx Microsphere Technology, to novel ways
of delivering proteins by such routes as intravenous release, inhalation
and buccal delivery.
Renal Builds on Portfolio Across Continuum of Kidney Disease Treatment
Al Heller, president
of Baxter's Renal business, highlighted a number of initiatives the company
has successfully implemented to strengthen its renal therapy portfolio
in addressing the entire continuum of care for patients with kidney disease.
Following its plans outlined at last year's growth conference to include
renal pharmaceuticals in its integrated approach to therapy for people
with end-stage renal failure, the company announced earlier today that
it has reached an agreement in principle with Watson Pharmaceuticals,
Inc. for the co-promotion of Ferrlecit® in the United States. Ferrlecit
(sodium ferric gluconate complex in sucrose injection) is a prescription
IV iron product used for the treatment of iron deficiency anemia in chronic
hemodialysis patients receiving supplemental epoetin therapy. The company
also announced today a licensing agreement with PrisMedical Corporation
for worldwide rights to sterile fluid technology for all renal applications.
Baxter and PrisMedical will co-develop products based on PrisMedical's
technology platform for producing sterile, dialysis-quality water at home
or point-of-use, using existing potable water sources. In late 2001, Baxter
acquired the rights to a proprietary recombinant erythropoieten for the
treatment of anemia, which is already approved for sale in 15 countries
outside the United States and Western Europe. The company continues to
explore opportunities that will enable it to provide products to better
manage uremic and dialysis-related complications, prevent or delay kidney
disease progression and treat diseases of the kidney.
Heller also highlighted Baxter's broad portfolio of peritoneal and hemodialysis
products, including Extraneal (7.5% icodextrin) peritoneal dialysis solution.
Extraneal is targeted for US regulatory approval in 2002, following a
recommendation for approval by the Cardiovascular and Renal Drugs Advisory
Committee to the US Food and Drug Administration (FDA) in late 2001. If
approved by the FDA, Extraneal will be the first solution with a new osmotic
agent introduced for peritoneal dialysis patients in the United States
since 1978.
Summarizing the overall impact of the company's combined offerings and
core technical competencies, Kraemer concluded, "Our complementary
portfolio of biopharmaceuticals, pharmaceuticals, medical devices and
services creates unique opportunities for Baxter to introduce novel therapeutic
approaches for some of the most challenging medical conditions facing
patients and clinicians worldwide."
Baxter International Inc. is a global medical products and services company
that, through its subsidiaries, provides critical therapies for people
with life-threatening conditions. Baxter's products and services in the
areas of bioscience, medication delivery and renal therapy are used by
health-care providers and their patients in more than 100 countries. Please
visit the company's website at www.baxter.com
for more information about Baxter (including the company's 2001 Annual
Report), and to access a webcast of this Annual Growth Conference (which
will be available live today and replayed until April 15).
This news release
contains forward-looking statements that involve risks and uncertainties,
including technological advances in the medical field, product demand
and market acceptance, the effect of economic conditions, actions of regulatory
bodies, the impact of competitive products and pricing, foreign currency
exchange rates and other risks detailed in the company's filings with
the Securities and Exchange Commission. These forward-looking statements
are based on estimates and assumptions made by management of the company
and are believed to be reasonable, though are inherently uncertain and
difficult to predict. Actual results or experience could differ materially
from the forward-looking statements.
(Baxter, Extraneal, InfluJect, INTERCEPT Blood System, INTERCEPT Platelet
System, INTERCEPT Plasma System, INTERCEPT Red Blood Cell System and NanoEdge
are trademarks of Baxter International Inc. and its affiliates. ProMaxx
is a trademark of Epic Therapeutics, and Ferrlecit is a trademark of Watson
Pharmaceuticals Inc.)
FOR ADDITIONAL
INFORMATION:
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- Media Contacts:
- Deborah Spak, 847-948-2349
Sally Benjamin Young, 847-948-2304
- Investor Contacts:
- Neville Jeharajah,
847-948-2875
Mary Kay Ladone, 847-948-3371
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