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CERUS AND
BAXTER REPORT INACTIVATION OF TRYPANOSOMA CRUZI PARASITE
Data Demonstrates
that Helinx Technology Inactivates Deadly Parasite Known to Cause Chagas
Disease
SAN ANTONIO, Tex., October, 15,
2001 - Cerus Corporation (Nasdaq: CERS) and Baxter Healthcare Corporation
today announced preclinical data demonstrating the ability of Helinx technology
to inactivate Trypanosoma cruzi (T. cruzi), a parasite that causes
a chronic and debilitating illness called Chagas disease. The parasite
can be transmitted through blood transfusion, but currently there are
no routine tests used to screen donated blood for this pathogen. The data
were presented at the American Association of Blood Banks (AABB) 54th
Annual Meeting in San Antonio.
"The exciting data demonstrate
the power of Helinx, with its DNA-targeting mechanism of action, to inactivate
these parasites," said Stephen T. Isaacs, president and chief executive
officer of Cerus. "These additional inactivation data will be used
to support regulatory submissions for the INTERCEPT Platelet System, our
first application of the Helinx technology, and will be added to results
showing that our technologies also inactivate viruses, bacteria and other
pathogens."
Kent Dupuis, the scientist who
heads the pathogen inactivation efforts at Cerus, presented the data at
the meeting. In the in vitro study, therapeutic doses of donor
platelets were inoculated with high levels of T. cruzi. The inoculated
blood was then treated with the Helinx process. The results demonstrated
inactivation and reduction of T. cruzi to undetectable levels.
T. cruzi, a parasite related
to the agent that causes African sleeping sickness, causes a life-threatening
infection called Chagas disease. Severe symptoms develop 10-20 years after
a period of chronic infection and include irreversible damage to internal
structures, namely the heart, esophagus and colon, and the peripheral
nervous system. Of those infected, approximately 25 percent develop cardiac
symptoms which may lead to sudden death. Although rare in the United States,
the World Health Organization estimates there are 18 million cases of
T. cruzi infection globally and that 100 million people are living
at risk. Treatments for Chagas disease are limited.
Cerus and Baxter are collaborating
on the development of the INTERCEPT Blood Systems, which utilize Helinx
technology, to enhance the safety of blood transfusions. The companies
are seeking U.S. and European approval of the INTERCEPT Platelet System
and are conducting a Phase III clinical trial of the INTERCEPT Plasma
System. In addition, the companies are preparing to begin a Phase III
clinical trial of the INTERCEPT Red Blood Cell System.
ABOUT CERUS
Cerus Corporation is developing medical systems and therapeutics based
on its proprietary Helinx technology for controlling biological replication.
Cerus' most advanced programs are focused on systems to enhance the safety
of the blood products used for transfusion. These INTERCEPT Blood Systems,
based on the company's Helinx technology, are designed to inactivate viruses,
bacteria, other pathogens and white blood cells. The Concord, California-based
company also is pursuing therapeutic applications of Helinx technology
to treat and prevent serious diseases.
ABOUT BAXTER
Baxter Healthcare Corporation is the principal domestic operating subsidiary
of Baxter International Inc. (NYSE: BAX). Baxter is a global medical products
and services company that, through its subsidiaries, provides critical
therapies for people with life-threatening conditions. The company's products
and services in bioscience (biopharmaceuticals, vaccines, biosurgery and
transfusion therapies), medication delivery and renal therapy are used
by health-care providers and their patients in more than 100 countries.
Helinx is a trademark of
Cerus Corporation
INTERCEPT Blood System, INTERCEPT Platelet System, INTERCEPT Plasma
System and INTERCEPT Red Blood Cell System are trademarks of
Baxter International Inc.
Statements in this news release
regarding product development and product potential are forward-looking
statements that involve risks and uncertainties. Actual results could
differ materially from the above forward-looking statements as a result
of certain factors, including the risks and uncertainty of the timing
and results of clinical trials and other development activities, actions
by regulatory authorities at any stage of the development process, additional
financing activities, market acceptance of any products, competitive conditions
and other factors discussed in the companies most recent reports on Forms
10K, 10Q and other filings with the Securities and Exchange Commission.
FOR ADDITIONAL
INFORMATION:
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- Media Contacts:
- Sylvia Wheeler
Director, Corporate Communications
Cerus Corporation
(925) 288-6061
- Media Contacts:
- Margaret
Stanford Shubny
Director, Corporate Communications
Baxter Healthcare Corporation
(847) 948-3951
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