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CERUS AND
BAXTER REPORT PHASE IIIa RESULTS
FOR THE INTERCEPT PLASMA SYSTEM
PARIS, France, July 16, 2001 -Cerus Corporation (Nasdaq: CERS)
and Baxter Healthcare Corporation today presented results from the Phase
IIIa clinical trial of the INTERCEPT Plasma System. These clinical trial
results further support the safety and efficacy of the system and showed
that clinical responses to INTERCEPT treated plasma are consistent with
historical responses to non-pathogen inactivated plasma. The INTERCEPT
Plasma System is being developed to protect against transmission of infectious
diseases that may result from plasma transfusions. The results were presented
at the VIIth European Congress of the International Society of Blood Transfusion
meeting in Paris.
The open-label Phase IIIa trial, which was conducted in collaboration
with the National Hemophilia Foundation's Hemophilia Research Society,
included 34 patients with a variety of hereditary blood clotting factor
deficiencies. Patients with these deficiencies are susceptible to bleeding
or increased blood clotting and may require plasma transfusions to prevent
or stop bleeding. The Phase IIIa results, although not statistically powered,
showed that infusions of plasma treated with the INTERCEPT Plasma System
were well-tolerated and resulted in an increase in blood clotting factor
levels consistent with historical controls of non-pathogen inactivated
plasma. In addition, INTERCEPT plasma effectively stopped or prevented
bleeding in patients requiring invasive procedures, including surgery,
and performed comparably to historical controls using non-pathogen inactivated
plasma.
Approximately seven million plasma transfusions are performed annually
in Western Europe, North America and Japan to overcome blood-clotting
deficiencies and to facilitate healing. While donated plasma is generally
tested for a limited number of specific pathogens, testing does not eliminate
the risk of viral contamination, and there are no routine tests to screen
for bacteria. The INTERCEPT Plasma System is being developed to enhance
the safety of plasma transfusions by targeting the nucleic acid of a broad
spectrum of viruses, bacteria, other pathogens and white blood cells.
Cerus and Baxter also are conducting a Phase III trial for the INTERCEPT
Platelet System and are preparing to begin a Phase III trial for the INTERCEPT
Red Blood Cell System.
ABOUT CERUS
Cerus Corporation is building on its leading position in the biopharmaceutical
industry by developing medical systems and therapeutics to provide safer
and more effective options to patients. The company is developing products
based on its proprietary Helinxä technology for controlling biological
replication. Cerus' most advanced programs are focused on systems to enhance
the safety of the world's blood supply. These INTERCEPT Blood Systems,
based on the company's Helinx technology, are designed to inactivate viruses,
bacteria, other pathogens and white blood cells. The Concord, California-based
company also is pursuing therapeutic applications of Helinx technology
to treat and prevent serious diseases.
ABOUT BAXTER
Baxter Healthcare Corporation is the principal domestic operating subsidiary
of Baxter International (NYSE: BAX). Baxter International, through its
subsidiaries, is a global medical products and services company that provides
critical therapies for people with life-threatening conditions. The company's
products and services in bioscience (biopharmaceuticals, vaccines, biosurgery
and transfusion therapies), medication delivery and renal therapy are
used by health-care providers and their patients more than 100 countries.
Helinx is a trademark of Cerus Corporation
INTERCEPT Blood System, INTERCEPT Platelet System, INTERCEPT Plasma
System and INTERCEPT Red Blood Cell System are trademarks of
Baxter International, Inc.
Statements in this news release regarding product development and product
potential are forward-looking statements that involve risks and uncertainties.
Actual results could differ materially from the above forward-looking
statements as a result of certain factors, including the risks and uncertainty
of the timing and results of clinical trials and other development activities,
actions by regulatory authorities at any stage of the development process,
additional financing activities, market acceptance of any products, competitive
conditions and other factors discussed in the companies' most recent reports
on Form 10Q and other filings with the Securities and Exchange Commission.
FOR ADDITIONAL
INFORMATION:
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- Media Contacts:
- Margaret
Stanford Shubny,
(847) 948-3951
Director, Corporate
Communications
Baxter Healthcare Corporation
Media Contacts:
- Sylvia
Wheeler,
(925) 288-6061
Director, Corporate
Communications
Cerus Corporation
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